In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Novel ATP-Competitive Kinesin Spindle Protein Inhibitors, published in 2007-10-04, which mentions a compound: 52287-51-1, mainly applied to biphenyl sulfonamide antitumor kinesin spindle protein inhibitor SAR, Computed Properties of C8H7BrO2.
Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has become a novel and attractive anticancer target with potential for reduced side effects compared to currently available therapies. We report herein the discovery of the first known ATP-competitive inhibitors of KSP, which display a unique activity profile as compared to the known loop 5 (L5) allosteric KSP inhibitors that are currently under clin. evaluation. Optimization of this series led to the identification of biphenyl sulfamide 20 (I), a potent KSP inhibitor with in vitro antiproliferative activity against human cells with either wild-type KSP (HCT116) or mutant KSP (HCT116 D130V). In a murine xenograft model with HCT116 D130V tumors, 20 showed significant antitumor activity following i.p. dosing, providing in vivo proof-of-principle of the efficacy of an ATP-competitive KSP inhibitor vs. tumors that are resistant to the other known KSP inhibitors.
When you point to this article, it is believed that you are also very interested in this compound(52287-51-1)Computed Properties of C8H7BrO2 and due to space limitations, I can only present the most important information.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics