Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17190-29-3, is researched, SMILESS is N#CCC(O)C1=CC=CC=C1, Molecular C9H9NOJournal, Article, Research Support, Non-U.S. Gov’t, Chemistry – A European Journal called Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition-Metal/NHC Complexes, Author is Sureshkumar, Devarajulu; Ganesh, Venkataraman; Kumagai, Naoya; Shibasaki, Masakatsu, the main research direction is beta hydroxynitrile enantioselective diastereoselective preparation; alkylnitrile aldehyde rhodium heterocyclic carbene catalyst addition reaction; N-heterocyclic carbenes; alkylnitriles; asymmetric catalysis; cooperative catalysis; rhodium.Recommanded Product: 17190-29-3.
Direct catalytic addition of alkylnitriles to aldehydes allowed for an atom-economical access to β-hydroxynitriles under proton transfer conditions. Direct use of alkylnitriles as pronucleophiles was hampered due to their low acidity resulting in an inability to generate α-cyano carbanions in a catalytic manner. A transition metal/N-heterocyclic carbene (NHC) complex prepared from [{Rh(OMe)(cod)}2] and an imidazolium-based carbene was identified as an effective catalyst to promote the reaction with as little as 1.25 mol % of catalyst loading. The corresponding Rh complex, derived from chiral triazolium salt, rendered the reaction enantioselective, albeit with moderate enantioselectivity.
This literature about this compound(17190-29-3)Recommanded Product: 17190-29-3has given us a lot of inspiration, and I hope that the research on this compound(3-Hydroxy-3-phenylpropanenitrile) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics