The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Hydroxy-3-phenylpropanenitrile(SMILESS: N#CCC(O)C1=CC=CC=C1,cas:17190-29-3) is researched.Safety of 4-(Piperazin-1-yl)phenol. The article 《Synthetic application of elemento-organic compounds of the 15th and 16th Groups. 92. Novel reaction of dibutyl(cyanomethyl)telluronium chloride with carbonyl compounds mediated by organolithium reagents: highly efficient synthesis of β-hydroxy nitriles》 in relation to this compound, is published in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). Let’s take a look at the latest research on this compound (cas:17190-29-3).
Dibutyl(cyanomethyl)telluronium chloride, a precursor of stabilized telluronium ylides, after being treated with organolithium reagents reacted with carbonyl compounds to afford β-hydroxy nitriles instead of α,β-unsaturated nitriles in excellent yields. Thus, reaction of Bu2Te+CH2CNCl- with BuLi in THF-hexane followed by treatment with PhCHO and hydrolysis gave 95% PhC(OH)CH2CN.
If you want to learn more about this compound(3-Hydroxy-3-phenylpropanenitrile)Name: 3-Hydroxy-3-phenylpropanenitrile, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17190-29-3).
Reference:
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics