17635-44-8, name is 3,4,5-Tribromopyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 17635-44-8
EXAMPLE 44 Preparation of 3,4,5-Tribromopyrazole-1-acetonitrile To a suspension of sodium hydride (2.2 gm. of a 60.6% dispersion in mineral oil, containing 0.055 mole of sodium hydride) in 60 ml. toluene was added a solution of 3,4,5-tribromopyrazole (15.2 gm., 0.05 mole) in 400 ml. hot toluene, followed by the dropwise addition of chloroacetonitrile (4.2 gm., 0.055 mole). The mixture was heated at the reflux temperature for 3 hrs. and then allowed to stand at about 25 C. for 18 hrs. Water (50 ml.) was added. The toluene layer was separated, washed with two 80-ml. portions of water, and dried with anhydrous sodium sulfate. Removal of the toluene gave 14.4 g. of 3,4,5-tribromopyrazole-1-acetonitrile as a white solid which was recrystallized from a mixture of ether and technical hexane.
Statistics shows that 17635-44-8 is playing an increasingly important role. we look forward to future research findings about 3,4,5-Tribromopyrazole.