82560-12-1,Some common heterocyclic compound, 82560-12-1, name is 3-Amino-5-tert-butylpyrazole, molecular formula is C7H13N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate A15: 3-(iert-Butyl)-1-(3-(2-methoxyethoxy)phenyl)-1 H-pyrazol-5-amine. Intermediate A15 To a solution of 1-iodo-3-(2-methoxyethoxy)benzene (1.18 g, 4.05 mmol) in anhydrous toluene (7.0 mL) was added 3-(ie/f-butyl)-1 – -pyrazol-5-amine (619 mg, 4.45 mmol) followed by (1R,2f?)-A/1,/V2-dimethylcyclohexane-1 ,2-diamine (255 mu, 1.62 mmol) and potassium carbonate (1.96 g, 14.2 mmol). The mixture was purged with nitrogen, after which copper(l) iodide (77 mg, 0.41 mmol) was added and the reaction mixture heated at reflux under nitrogen for 18 hr. The resulting mixture was cooled to RT and was partitioned between EtOAc (250 mL)and water (250 mL). The organic layer was separated and was washed with water (2 x 250 mL) and brine (250 mL) and was then dried and evaporated in vacuo. The residue was purified by flash column chromatography (Si02, 120 g, 0-5% [0.7 M NH3 in MeOH] in DCM, gradient elution) to afford the title compound, Intermediate A15, as a brown gum (1.04 g, 84%); Rl 2.20 min (Method 1 , acidic); m/z 290 (M+H)+ (ES+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Amino-5-tert-butylpyrazole, its application will become more common.