16461-94-2, These common heterocyclic compound, 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Amino-4-bromopyrazole (0.331 g, 2.04 mmol) and 3-(dime1hylamino)-2-methyl-2-propenal (0.220 g, 1.94 mmol) were dissolved in acetic acid (6.48 mL) and ethanol (9.72 mL) and the reaction stirred at room temperature for 1 h. Solvents were removed under reduced pressure. The remaining residue was taken up in dichloromethane and purified by column chromatography (20- 80% EtO Ac/Hex) to give the title compound (0.294 g, 1.39 mmol). LRMS (APCI) calc’d for (C7H6BrN3) [M+H , 212.0; found 211.9. 1H NMR (500 MHz, cdcl3) delta 8.44 (s, 2H), 8.04 (s, 1H), 2.40 (s, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 16461-94-2.