These common heterocyclic compound, 6076-12-6, name is Ethyl 4-methyl-1H-pyrazole-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 6076-12-6
Ethyl 4-methyl-1 H-pyrazole-3-carboxylate (Intermediate 33) (1.0 g, 6.49 mmol) was dissolved in DMF : H20 (9.0 mL : 1.0 mL) and K20O3(3.58 g, 25.9 mmol) and sodium 2-chloro-2,2-difluoroacetate (Intermediate 35) (3.94 g, 25.9 mmol) were added at 0 C and then the mixture was heated at 130 C for 20 min. The reaction mixture was cooled to RT and ice-cold water was added. The aqueous layer was extracted with EtOAc (3 x 50 mL) and the combined organic layer was washed with brine solution, dried over Na2S04, filtered and concentrated. The residue was purified by column chromatography (Normal-Phase 60-120 mesh silica gel, 25 % EtOAc in hexanes) to give ethyl 1- (difluoromethyl)-4-methyl-1 /-/-pyrazole-3-carboxylate (325 mg, 25 %) as a solid.LCMS (System 3, Method D): m/z 205 (M+H)+(ESI +ve), at 3.77 min, 202 nm.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6076-12-6.