31037-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Alternative preparation according to Process B: 540g (2.26 mmol) of 2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulphanyl]aniline are initially charged in dry dichloromethane.The flask is flushed with argon, and 2.5 ml of a 2Msolution of trimethylaluminium in toluene are added dropwise.The reaction mixture is stirred at room temperature for30min, and405 mg (2.39 mmol) ofethyl5-amino-1-methyl-1H-pyrazole-4-carboxylate are then added. The mixture isstirred at room temperature overnight, and a 1 0% strengthpotassium/sodium tartrate solution is then added. The organicphase is separated off and the aqueous phase is extractedtwice with dichloromethane. The combined organic phasesare dried over sodium sulphate and the mixture is applied toRP(C-18) material. Removal of the solvents is followed bypurification by means of MPLC on an RP(C-18) columnusing water/acetonitrile. This gives 577 mg (1 00% pure, 71%of theory) of the title compound.
The synthetic route of 31037-02-2 has been constantly updated, and we look forward to future research findings.