35344-95-7, A common heterocyclic compound, 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, molecular formula is C4H4N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 1H- pyrazole-4-carbaldehyde 13-4 (220 mg, 2.29 mmol) in DMF (5 mL) was added cesium carbonate (1.86 g, 5 72 mmol) and cyclohexyl methanesulfonate 13-3 (489.74 mg, 2.75 mmol). The reaction mixture was heated at 60C for 16 hours. The reaction mixture was quenched with cold water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous solution of NaHCCb, dried over NaiSCh and concentrated under reduced pressure to afford crude which was purified by column chromatography to afford l-cyclohexylpyrazole-4-carbaldehyde 13-5 (220 mg, 1.23 mmol, 53.91 % yield) as gummy liquid. LC MS: ES+ 179.
The synthetic route of 35344-95-7 has been constantly updated, and we look forward to future research findings.