Safety of 3,5-Dimethyl-1H-pyrazole. Fosu, SC; Hambira, CM; Chen, AD; Fuchs, JR; Nagib, DA in [Fosu, Stacy C.; Chen, Andrew D.; Nagib, David A.] Ohio State Univ, Dept Chem & Biochem, Columbus, OH 43210 USA; [Hambira, Chido M.; Fuchs, James R.] Ohio State Univ, Coll Pharm, Div Med Chem & Pharmacognosy, Columbus, OH 43210 USA published Site-Selective C-H Functionalization of (Hetero)Arenes via Transient, Non-symmetric lodanes in 2019.0, Cited 51.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6.
A strategy for C-H functionalization of arenes and heteroarenes has been developed to allow site-selective incorporation of various anions, including Cl, Br, OMs, OTs, and OTf. This approach is enabled by in situ generation of reactive, non-symmetric iodanes by combining anions and bench-stable Phl(OAc)(2). The utility of this mechanism is demonstrated via para-selective chlorination of medicinally relevant arenes, as well as site-selective C-H chlorination of heteroarenes. Spectroscopic, computational, and competition experiments describe the unique nature, reactivity, and selectivity of these transient, unsymmetrical iodanes.
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Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics