What Kind of Chemistry Facts Are We Going to Learn About 3,5-Dimethyl-1H-pyrazole

Welcome to talk about 67-51-6, If you have any questions, you can contact Bencheva, LI; De Matteo, M; Ferrante, L; Ferrara, M; Prandi, A; Randazzo, P; Ronzoni, S; Sinisi, R; Seneci, P; Summa, V; Gallo, M; Veneziano, M; Cellucci, A; Mazzocchi, N; Menegon, A; Di Fabio, R or send Email.. Recommanded Product: 3,5-Dimethyl-1H-pyrazole

An article Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS WOS:000464767700041 published article about ASICS; PHARMACOLOGY; DIMINAZENE; ASSAY; PH in [Bencheva, Leda Ivanova; De Matteo, Marilenia; Ferrante, Luca; Ferrara, Marco; Prandi, Adolfo; Randazzo, Pietro; Ronzoni, Silvano; Sinisi, Roberta; Seneci, Pierfausto; Di Fabio, Romano] Promidis, Via Olgettina 60, I-20132 Milan, Italy; [Mazzocchi, Nausicaa; Menegon, Andrea] Ist Sci San Raffaele, Expt Imaging Ctr, ALEMBIC, Adv Light & Electron Microscopy BioImaging Ctr, Via Olgettina 60, I-20132 Milan, Italy; [Summa, Vincenzo; Gallo, Mariana; Veneziano, Maria; Cellucci, Antonella] IRBM Sci Pk,Via Pontina Km 30-600, I-00070 Rome, Italy; [Seneci, Pierfausto] Univ Milan, Dept Chem, Via Golgi 19, I-20133 Milan, Italy; [Ferrara, Marco] Flamma Innovat Srl, Via Cascina Secchi 217, I-24040 Isso, BG, Italy in 2019.0, Cited 27.0. Recommanded Product: 3,5-Dimethyl-1H-pyrazole. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6

Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chemical starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound 2u is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies.

Welcome to talk about 67-51-6, If you have any questions, you can contact Bencheva, LI; De Matteo, M; Ferrante, L; Ferrara, M; Prandi, A; Randazzo, P; Ronzoni, S; Sinisi, R; Seneci, P; Summa, V; Gallo, M; Veneziano, M; Cellucci, A; Mazzocchi, N; Menegon, A; Di Fabio, R or send Email.. Recommanded Product: 3,5-Dimethyl-1H-pyrazole

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics