The important role of 288-13-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-13-1.

These common heterocyclic compound, 288-13-1, name is 1H-Pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 288-13-1

1 H-Pyrazol-4-ylamine[00391] Step i :[00392] Pyrazole (3.4g, 50mmol) was added in portions to cone sulfuric acid (25mL) while keeping the reaction temperature below 400C. To this solution was then added 70% nitric acid (3.5 mL) dropwisely while maintaining the temperature below 55C. The mixture was stirred at this temperature for 4 hours. After cooling to room temperature, the mixture was slowly poured into 500 grams of ice. The resultant mixture was neutralized with 50% aqueous NaOH and the resulting slurry was diluted with 50OmL of ethyl acetate. This mixture was filtered and the filtrate was washed with water (300ml), brine (300ml), and dried over Na2SO4. The solution was concentrated, and the precipitate was colleted and dried in vacuo to afford the title compound as white crystals. MS (ES) [M+H]+ expected 1 13.0, found 1 13.0.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 288-13-1.