5932-27-4, name is Ethyl 1H-pyrazole-3-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 5932-27-4
General procedure: To a suspension of NaH (60percent) (229 mg, 1.91 mmol) in DMF (10 mL) under nitrogen atmosphere a solution of Preparation 21 (660 mg, 1.91 mmol) in DMF (8 mL) was added. The mixture was stirred at room temperature for 30 min and then ethyl 2-bromo-2,2-difluoroacetate (586 muL, 3.81 mmol) in DMF (8 mL) was added and the reaction mixture stirred overnight at r.t. Solvent was removed and the residue was dissolved in ethyl acetate, washed with water and brine, dried over magnesium sulphate and concentrated. The crude was purified according to the General Purification Method to give the desired compound (10percent yield). LRMS: m/z 469 (M+1)+ Retention time: 7.77 min (Method B); Obtained (35percent) from Preparation 172 and iodoethane following the procedure described in Preparation 23, using dioxane as solvent. LRMS: m/z 169 (M+1)+ Retention time: 2.40 min (Method A) 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.38 (t, J=7.23 Hz, 3 H) 1.44 (t, J=7.23 Hz, 3 H) 4.35 (q, J=7.16 Hz, 2 H) 4.61 (q, J=7.29 Hz, 2 H) 6.83 (d, J=1.95 Hz, 1 H) 7.48 (d, J=1.95 Hz, 1 H).
Statistics shows that 5932-27-4 is playing an increasingly important role. we look forward to future research findings about Ethyl 1H-pyrazole-3-carboxylate.