Authors Hawsawi, M; Pirrone, MG; Wickramasinghe, A; Crich, D in ELSEVIER SCI LTD published article about ALKENEDIAZONIUM SALTS; STEREOSELECTIVE-SYNTHESIS; HEXACHLOROANTIMONATE; REARRANGEMENT; CRYSTAL; ESTERS in [Hawsawi, Mohammed; Pirrone, Michael G.; Wickramasinghe, Anura; Crich, David] Wayne State Univ, Dept Chem, 5101 Cass Ave, Detroit, MI 48202 USA; [Pirrone, Michael G.; Wickramasinghe, Anura; Crich, David] Univ Georgia, Dept Pharmaceut & Biomed Sci, 250 West Green St, Athens, GA 30602 USA; [Crich, David] Univ Georgia, Dept Chem, 140 Cedar St, Athens, GA 30602 USA; [Crich, David] Univ Georgia, Complex Carbohydrate Res Ctr, 315 Riverbend Rd, Athens, GA 30602 USA in 2020.0, Cited 32.0. Formula: C5H8N2. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6
The oxidative deamination of N-nitroso N-acetylneuraminic acid (NeuAc) derivatives is a useful reaction for the formation of 5-desamino-5-hydroxy NeuAc derivatives and their stereoisomers. We demonstrated previously that replacement of the classical nucleophile in these reactions, acetic acid, by phenols resulted in a novel double displacement process with substitution of the acetoxy group at the 4-position taking place in addition to that of the 5-acetamido group, for which we postulated a mechanism centered on the formation of a highly reactive vinyl diazonium ion. We now extend these studies to encompass the use of hydroxylaminebased systems and weakly basic amines as nucleophile. We find that the nature of the product depends significantly on the pKa of the nucleophile, with the more acidic species typically affording only substitution at the 5-position, while the less acidic species give mixtures of elimination products and disubstitution products. The use of aniline as nucleophile is of particular note as it affords a novel aziridine spanning positions 4- and 5- of the neuraminic acid skeleton.
Welcome to talk about 67-51-6, If you have any questions, you can contact Hawsawi, M; Pirrone, MG; Wickramasinghe, A; Crich, D or send Email.. Formula: C5H8N2
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics