Recently I am researching about DRUG-DELIVERY; ANTICANCER DRUG; ACID; LIPOSOME; VULGARIS; EFFICACY; PROBE, Saw an article supported by the Huxiang Young Talent Support Program of Hunan Province [2018RS3005]; Project of Innovation-Driven Project of Central South University [2020CX048]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ60071]; Shenghua Yuying Project of Central South University; Postgraduate Innovation Project of Central South University [2019zzts449, 2019zzts750, 2019zzts1017]; Hunan Provincial Innovation Foundation for Postgraduate [CX20190184, CX20190242]; Scientific Research Foundation of Hunan Provincial Education DepartmentHunan Provincial Education Department [18A211]. Quality Control of 3,5-Dimethyl-1H-pyrazole. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Du, PF; Yan, JH; Long, S; Xiong, HJ; Wen, NC; Cai, SD; Wang, YR; Peng, DM; Liu, ZB; Liu, YF. The CAS is 67-51-6. Through research, I have a further understanding and discovery of 3,5-Dimethyl-1H-pyrazole
A berberine 9-O-pyrazole alkyl derivative, a chemical compound (called B3) previously synthesized by our group, shows anti-cancer activity. However, B3 lacks targeting cytotoxicity to cancer cells, leading to obvious toxic side effects on normal cells. To solve this problem, here, we prepared a drug delivery system, namely, AS1411-GO/B3 for tumor targeting, in which nano-graphene oxide (GO) sheets were employed as the drug carrier, and the aptamer AS1411 was conjugated onto GO for tumor targeting. GO also had a photothermal effect, which helped the release of B3 from GO as well as the thermal cytotoxicity to cells. We found that the release of B3 could respond to acid conditions, indicating that the tumor intracellular environment could promote the release of B3, thus allowing it to perform chemotherapy effects. This system could also release B3 in response to photothermal heating, moreover, combined photothermal therapy and chemotherapy to improve the anticancer activity was achieved. This AS1411-GO/B3 platform with chemo-photothermal synergetic therapy provides a very promising treatment for tumors.
Quality Control of 3,5-Dimethyl-1H-pyrazole. Welcome to talk about 67-51-6, If you have any questions, you can contact Du, PF; Yan, JH; Long, S; Xiong, HJ; Wen, NC; Cai, SD; Wang, YR; Peng, DM; Liu, ZB; Liu, YF or send Email.
Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics