In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 83-10-3 as follows. 83-10-3
To a suspension of 4-amino-5-chloro-2-fluorophenol (0.97 g, 6 mmol), 1,5- dimethyl-3-oxo-2-phenyl-2,3-dihydro-lH-pyrazole-4-carboxylic acid (1.42 g, 6.12 mmol) in DMF (20 mL) was added EDCI (0.38 mg, 7.2 mmol) and HOAT (0.16 g, 1.2 mmol). The reaction mixture was heated to 80 C and stirred for 24 hours, then cooled to 0 C, and diluted with H20 (200 mL) and EtOAc (2 mL) at 0 C. The resulted mixture was filtered to give the title compound as a light brown solid (1.2 g, 53.2%). MS (ESI, pos. ion) m/z: 376.1 [M+H]+; NMR (400 MHz, DMSO-i): delta 2.68 (s, 3H), 3.34 (s, 3H), 7.03 (d, J= 8.8 Hz, 1H), 7.41-7.43 (m, 2H), 7.48-7.52 (m, 1H), 7.56-7.60 (m, 2H), 8.31 (d, J= 13.8 Hz, 1H), 10.08 (s, 1H), 10.95 (s, 1H).
According to the analysis of related databases, 83-10-3, the application of this compound in the production field has become more and more popular.