A common compound: 3112-31-0, name is 1H-Pyrazole-3,5-dicarboxylic acid, belongs to pyrazoles-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 3112-31-0
A.5-[(R)-2-Biphenyl-4-yl-1-(1-carboxy-cyclopropylmethyl)-ethylcarbamoyl]-2H-pyrazole-3-carboxylic acid (R7=H)3,5-Pyrazoledicarboxylic acid (35.2 mg, 226 mumol, 1.0 eq.), DIPEA (126 muL) and HATU (85.9 mg, 226 mumol, 1.0 eq.) and DCM (5 mL) were combined and stirred for 5 minutes at room temperature. 1-((R)-2-Amino-3-biphenyl-4-yl-propyl)-cyclopropanecarboxylic acid (86.7 mg, 294 mumol, 2.3 eq,) and DIPEA (0.5 mL) in DCM (5 mL) was added, and the resulting mixture was stirred for 1 hour.The reaction was quenched with saturated aqueous NH4Cl and the product was extracted with DCM, dried and evaporated.The resulting product was combined with AcOH (1.5 mL) and purified with preparative HPLC to yield the title compound (21.4 mg; 93percent purity). MS m/z [M+H]+ calc’d for C24H23N3O5, 434.16; found 433.5.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3112-31-0, other downstream synthetic routes, hurry up and to see.