An update on the compound challenge: 3,5-Dimethyl-1H-pyrazole

Quality Control of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Purkait, K; Mukherjee, A or concate me.

In 2020.0 INORG CHIM ACTA published article about ANTICANCER; QUINONES; CANCER; GLUTATHIONE; DERIVATIVES; ANTIFUNGAL; ACTIVATION; RUTHENIUM; REDUCTASE; DESIGN in [Purkait, Kallol; Mukherjee, Arindam] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Nadia 741246, India in 2020.0, Cited 62.0. The Name is 3,5-Dimethyl-1H-pyrazole. Through research, I have a further understanding and discovery of 67-51-6. Quality Control of 3,5-Dimethyl-1H-pyrazole

Quinone based compounds display activation in hypoxia, an environment prevalent in tumours. We have synthesized a bis(pyrazole) based 1,4-quinone compound suitable for metal chelation. The quinone (L2) converted to hydroquinone (H(2)L1) during the complex synthesis leading to [Ru-II(eta(6)-p-cym)(H(2)L1)Cl](PF6) (1). We found from ‘FINMR studies that in the methanolic solution L2 stoichiometrically converted to H(2)L1 while oxidizing the methanol to formaldehyde. L2 crystallized in monoclinic space group I2/a while complex 1 crystallizes in P2(1)/c. Cyclic voltammetry of the redox non-innocent L2 showed quasi-reversible (Delta Ep = 67 mV) redox behaviour with E-1/2 at 0.12 V w.r.t. NHE. Complex 1 is stable at pH 7.4 in presence of 4 mM chloride and does not hydrolyse even up to 24 h. L2 showed IC50, values of 155 and 123 mu M against metastatic breast adenocarcinoma (MDA-MB231) and pancreatic carcinoma (MIA PaCa-2) respectively. L2 gets activated by ca. 2.7-fold in hypoxia against MIA PaCa-2 cells. The mechanistic studies showed ROS accumulation and oxidation of NADH to NAD(+), which may be responsible for the cytotoxicity. The reactivity studies showed that conversion to hydroquinone by reaction with NADH or glutathione is irreversible. Complex 1 is not cytotoxic up to 100 mu M in normoxia or hypoxia. Complex 1 displays irreversible redox behavior in cyclic voltammetry displaying two overlapping oxidation peaks at 1.00 and 1.57 V w.r.t. NHE, which may be assigned to the conversion of hydroquinone to quinone and Ru-II -> Ru-III respectively.

Quality Control of 3,5-Dimethyl-1H-pyrazole. About 3,5-Dimethyl-1H-pyrazole, If you have any questions, you can contact Purkait, K; Mukherjee, A or concate me.

Reference:
Pyrazole – Wikipedia,
,Pyrazoles – an overview | ScienceDirect Topics