Related Products of 15802-75-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15802-75-2, name is 4-Iodo-3-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
Under nitrogen protection,To a 10 ml Schlek reaction tube (a glass instrument commonly used in anhydrous oxygenless operation) was added 1.0 mmol2-iodo-5- (2-iodopyrimidine-3) pyrimidine, 2.0 mmol of 3-methyl-4-iodopyrazole, 0.03 mmol of palladium acetate,0.05 mmol di-t-butyl (2 ‘, 4′, 6′-triisopropyl-3,6-dimethoxybiphenyl-2-yl)4.0 mmol of sodium tert-butoxide, and 5 ml of toluene, the reaction tube was purged with nitrogen three times,And then heated to 110 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. Down to room temperatureThe reaction solution was further added, 3.0 mmol of 4-carboxyphenylboronic acid, 0.02 mmol of palladium acetate, 0.04 mmol2′-dicyclohexyl-2,6-dimethoxy-3-sulfonic acid-1,1’-biphenyl sodium salt, 7.0 mmol sodium carbonate,And 100 mmol of water; then heated to 100 C with an oil bath under magnetic stirring and the reaction was refluxed for 24 hours.Down to room temperature; add 20 ml of water, filtration, with concentrated hydrochloric acid to adjust the pH of the filtrate to 1, room temperature stirring 3h,Filtered, washed with ethanol, dried product 16, yield 72%. The product (C30H22N8O4)Of the mass spectrum (ESI) of 558.20.
The chemical industry reduces the impact on the environment during synthesis 4-Iodo-3-methyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Luoyang Normal College; Li Hongmei; Xu Chen; Wang Zhiqiang; Tu Tianyong; Hao Xinqi; (10 pag.)CN106674208; (2017); A;,
Pyrazole – Wikipedia,
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