Adding a certain compound to certain chemical reactions, such as: 10250-64-3, name is 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10250-64-3, Recommanded Product: 10250-64-3
(R) -1,1,1-trifluoro-2-((S) -5-methyl-5,6,7,8-tetrahydro [1,2,4] triazolo [4] obtained in the previous step , 3-a] pyrazin-3-yl) propan-2-ol dihydrochloride (39 mg) and 1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid (29.1 mg) were added to dimethylformamide (0. 6mL). below freezing,To this mixture was added diisopropylethylamine (83 muL) and HATU (55 mg),Stir at room temperature overnight.Under ice-cooling, a saturated aqueous sodium hydrogen carbonate solution and water were added to the reaction mixture, and the mixture was extracted with ethyl acetate.Organic layer with saturated aqueous sodium bicarbonate solution,Washed sequentially with water and saturated aqueous sodium chloride solution. The organic layer was dried with sodium sulfate.Sodium sulfate was removed by filtration, and the filtrate was concentrated under reduced pressure.The obtained residue was purified by silica gel column chromatography (hexane: ethyl acetate = 2: 1 to chloroform: methanol = 20: 1).Add ethyl acetate and hexane to the resulting solid,Stir at room temperature for 1 hour.By filtering the solid,The title compound (41.7 mg) was obtained.
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Reference:
Patent; japan Tobacco Inc.; Maeba, Takaki; Sazawa, Koichi; Kotoku, Masayuki; Masuo, Ritsuki; Motoda, Dai; Yamaoka, Nobutaka; (126 pag.)JP2019/131544; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics