Synthetic Route of 3524-32-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3524-32-1, name is 5-Amino-1,3-dimethylpyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: A 0.5M solution of NaOH in water (100mL) containing aminopyrazole 1 (3mmol, 0.29g) was placed into a glass cell with a cylindrical Ni anode (S=48cm2, activated before the synthesis according to the literature procedure23) and a Ti cathode (S=20cm2). Electrolysis was carried out at a current of 290mA. After passing 2F of electricity per mol of the substrate (Q=579C), the electrolysis was stopped. The reaction mixture was stirred for 0.5h and concentrated HCl was added until the solution was pH ?3. The mixture was then extracted with CHCl3 (3×40mL). The extracts were combined, dried over Na2SO4 and concentrated in vacuo. Column chromatography on silica with light petroleum ether:ethyl acetate (10:1) gave the pure azopyrazole 1a (82%, 0.47g).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Amino-1,3-dimethylpyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Lyalin, Boris V.; Sigacheva, Vera L.; Kokorekin, Vladimir A.; Petrosyan, Vladimir A.; Tetrahedron Letters; vol. 59; 28; (2018); p. 2741 – 2744;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics