Application of 18048-64-1, These common heterocyclic compound, 18048-64-1, name is 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 8; 3- {N’-[ 1 -(3,4-Dimethyl-phenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]- hydrazino)-biphenyl-2,3′-dicarboxylic acid (Compound 108) was prepared as described in Scheme II. ¹H NMR (500 MHz, Acetone-d6) 8 8.10-8.06 (m, 2H), 7.77-7.68 (m, 4H), 7.60 (t, J= 7.6 Hz, 1H), 7.30 (dd, J= 7.8, 1.0 Hz, 1H), 7.19 (d, J= 8.3 Hz, 1H), 2.36 (s, 3H), 2.30 (s, 3H), 2.26 (s, 3H).
The synthetic route of 18048-64-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LIGAND PHARMACEUTICALS INC.; WO2005/118551; (2005); A2;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics