Synthetic Route of 821767-61-7, The chemical industry reduces the impact on the environment during synthesis 821767-61-7, name is tert-Butyl 4-formyl-1H-pyrazole-1-carboxylate, I believe this compound will play a more active role in future production and life.
Example 15 tert-butyl 4-formyl-1H-pyrazole-1-carboxylate (1.0 g) and (6-isopropylpyridin-3-yl)amine (0.694 g) were dissolved in 1,2-dichloroethane (25 mL), acetic acid (0.29 mL) and sodium triacetoxyborohydride (2.16 g) were added, and the mixture was stirred overnight at room temperature. The reaction mixture was poured into saturated aqueous sodium hydrogencarbonate, and the mixture was partitioned and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography to give tert-butyl 4-{[(6-isopropylpyridin-3-yl)amino]methyl}-1H-pyrazole-1-carboxylate (1.46 g). 1H-NMR(CDCl3)delta: 1.26(6H,d,J=6.9Hz), 1.65(9H,s), 2.96(1H,sept,J=6.9Hz), 3.80-3.90(1H,m), 4.23(2H,d,J=6.0Hz), 6.88(1H,dd,J=3.0,8.4Hz), 6.99(1H,d,J=8.4Hz), 7.70(1H,s), 8.01(1H,d,J=3.0Hz), 8.04(1H,s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 4-formyl-1H-pyrazole-1-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Mitsubishi Pharma Corporation; EP1852431; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics