Synthetic Route of 31230-17-8,Some common heterocyclic compound, 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, molecular formula is C4H7N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of NaH (220 mg, 5.50 mmol) in anhydrous THF (3.5 mL) was added a solutionof 3-amino-5-methyl-1H-pyrazole (500 mg, 5.00 mmol) in anhydrous THF (6.5 mL) at 0 °C under argon atmosphere. After stirring for 30 min, Boc2O (1.31 mL, 5.50 mmol) was added and stirred at rt for 5.5 h. After the completion of the reaction, the mixture was quenched with saturated aqueous NaHCO3 (100 mL) and extracted with CH2Cl2 (4 × 75 mL). The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated by rotary evaporation. Purification by column chromatography (1:1 ? 1:2 hexanes/EtOAc) yielded S1r(377 mg, 38percent) as a light brown solid and S1r’ (472 mg, 48percent) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methyl-1H-pyrazol-3-amine, its application will become more common.
Reference:
Article; Jeong, Yunkyung; Lee, Jooyeon; Ryu, Jae-Sang; Bioorganic and Medicinal Chemistry; vol. 24; 9; (2016); p. 2114 – 2124;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics