Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56984-32-8, name is Ethyl 5-chloro-1-methyl-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., category: pyrazoles-derivatives
The 1 – methyl -5 – chlorine pyrazole -4 – formic acid ethyl ester (300 mg, 1 . 59 mmol), phenol (300 mg, 3 . 19 mmol) dissolved in DMF, is added cesium carbonate (1.52, 4 . 66 mmol), microwave reactor 130 C reaction 30 minutes, the reaction is finished, to be reaction liquid cooling to room temperature, poured into water, extracted with ethyl acetate, the organic layer using saturated salt water washing, drying of the organic layer, dryness, passes through the rapid preparation column purification product 280 mg, yield is 72%.
The synthetic route of 56984-32-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Shen Jianhua; Leng Ying; Zou Qingan; Ning Mengmeng; (116 pag.)CN105164112; (2017); B;,
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