Reference of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 5-cyclopropyl-1H-pyrazol-3-amine (0.267 g, 2.17 mmol) and 2,4,6-trichloroquinazoline (0.432 g, 2.17 mmol) in dimethylformamide (DMF) (10 mL) was treated with EtN(i-Pr)2 (0.49 mL, 2.82 mmol) and stirred for 4 h at 0 C. The reaction mixture was poured over ice water. The solid was collected by filtration and dried in air to provide compound 5 without further purification [16]. The yield was 74.6%.
The synthetic route of 175137-46-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wu, Tianxiao; Pang, Yu; Guo, Jing; Yin, Wenbo; Zhu, Mingyue; Hao, Chenzhou; Wang, Kai; Wang, Jian; Zhao, Dongmei; Cheng, Maosheng; Molecules; vol. 23; 2; (2018);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics