Application of 52222-73-8, The chemical industry reduces the impact on the environment during synthesis 52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, I believe this compound will play a more active role in future production and life.
100 mg (0.24 mmol) of 2-(6-chloro-3-ethylsulphonyl-2-pyridyl)-3-methyl-6-(trifluoromethyl)imidazo[4,5-c]pyridine were dissolved in 10 ml of acetonitrile, 41 mg of potassium carbonate (0.29 mmol) and 100.8 mg of 4-(trifluoromethyl)-1H-pyrazole (0.74 mmol) were added and the mixture was then stirred at 65 C. for 4 h. The reaction mixture was then filtered through a silica gel cartridge using ethyl acetate. The solvent was distilled off under reduced pressure and the residue was purified by column chromatography using a water/acetonitrile gradient as mobile phase. (log P (neutral): 3.34; MH+: 471; 1H-NMR (400 MHz, D6-DMSO) delta ppm: 1.23 (t, 3H), 3.83 (q, 2H), 4.00 (s, 3H), 8.16 (s, 1H), 8.33 (s, 1H), 8.35 (d, 1H), 8.68 (d, 1H), 8.98 (s, 1H), 9.35 (s, 1H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethyl)-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER CROPSCIENCE AKTIENGESELLSCHSAFT; FISCHER, RUEDIGER; WILCKE, DAVID; ILG, KERSTIN; GOERGENS, ULRICH; PORTZ, DANIELA; EILMUS, SASCHA; TURBERG, ANDREAS; (80 pag.)US2018/2345; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics