Application of 152120-54-2, These common heterocyclic compound, 152120-54-2, name is tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: N,N-diBoc-1H-pirazole-1-carboxamidine (0.8 g, 1eq) was dissolved in anhydrous THF (10 mL), then triphenylphosphine (1.01 g, 1.5eq) and the appropriate alcohol (1.3 eq) were. The mixture was then cooled to 0 C and DIAD (0.76 mL, 1.5eq) was added dropwise. The temperature was raised to reflux and stirred overnight. The reaction was quenched with H2O and extracted with CH2Cl2 (3 x 30 mL). The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure. The crude products were purified by flash column chromatography (SiO2) using 1:9 AcOEt / Petroleum ether as the eluent to yield the guanilated agent.
Statistics shows that tert-Butyl (((tert-butoxycarbonyl)amino)(1H-pyrazol-1-yl)methylene)carbamate is playing an increasingly important role. we look forward to future research findings about 152120-54-2.
Reference:
Article; Maccari, Giorgio; Sanfilippo, Stefania; De Luca, Filomena; Deodato, Davide; Casian, Alexandru; Dasso Lang, Maria Chiara; Zamperini, Claudio; Dreassi, Elena; Rossolini, Gian Maria; Docquier, Jean-Denis; Botta, Maurizio; Bioorganic and Medicinal Chemistry Letters; vol. 24; 23; (2014); p. 5525 – 5529;,
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