Adding a certain compound to certain chemical reactions, such as: 1018446-95-1, name is tert-Butyl 4-amino-1H-pyrazole-1-carboxylate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1018446-95-1, name: tert-Butyl 4-amino-1H-pyrazole-1-carboxylate
Intermediate 6 (220 mg, 0.67 mmol), triphosgene (66 mg, 0.22 mmol) and dry THF (5 mE) were sequentially added to a 10 mE three-necked flask. Under nitrogen protection, the reaction mixture was cooled to 00 C., and slowly added with DIPEA (173 mg, 1.34 mmol) dropwise. The reaction mixture was stirred for 10 mm. Then Intermediate 9 (240 mg, 1.34 mmol) was quickly added to the reaction mixture. The reaction mixture was stirred at room temperature overnight, concentrated, and purified by reversed phase column chromatography to give Intermediate 10 (95 mg, 32.4% yield) as a white solid. Because of there is TFA in solution, Intermediate 10 is converted to Compound of Formula Ic during lyophilization.
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Reference:
Patent; YIN, JIANMING; (11 pag.)US2019/169163; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics