Reference of 15366-34-4,Some common heterocyclic compound, 15366-34-4, name is Methyl 1H-pyrazole-3-carboxylate, molecular formula is C5H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1 -Chloro-4-iodo-benzene (3.5 g, 14.7 mmol), methyl 1 H-pyrazole-3-carboxylate (1.85 g, 14.7 mmol) and Cul (0.235 g, 1.47 mmol), L-proline (0.405 g, 2.94 mmol), K2C03 (4.1 g, 29.4 mmol) in DMSO (40ml_) were stirred at 90 C for10 hours. The reaction mixture was filtered and the organic layer was diluted with EtOAc (300 ml_), washed with brine (100 ml. x 3), and dried over Na2S04. Evaporation of the solution on a water bath under reduced pressure gave methyl 1 -(4-chlorophenyl)pyrazole-3-carboxylate (2.3 g, 66% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 1H-pyrazole-3-carboxylate, its application will become more common.
Reference:
Patent; BASF SE; WINTER, Christian; RHEINHEIMER, Joachim; WOLF, Antje; TERTERYAN, Violeta; POONOTH, Manojkumar; WIEBE, Christine; KREMZOW-GRAW, Doris; ROeHL, Franz; ROHRER, Sebastian Georgios; WIEJA, Andy; ROSENBAUM, Claudia; GRAMMENOS, Wassilios; WO2014/202703; (2014); A1;,
Pyrazole – Wikipedia,
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