In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3112-31-0 as follows. Product Details of 3112-31-0
To a 25 mL reactor, 174.0 mg of 3,5-pyrazoledicarboxylic acid monohydrate and 250.0 mg of copper sulfate pentahydrate powder were added, 5 mL of pyridine and 10 mL of water were added, and after stirring for 15 minutes, the reaction kettle was placed in an oven and heated to 180. °C, reaction for 24 hours; After the reaction is completed, the reaction solution is transferred to a flask, and 2 mL of a saturated aqueous solution of sodium sulfide is added to the reaction solution, and after the precipitation is completed, it is filtered:Add 1M hydrochloric acid solution to the filtrate droplet obtained in the second step, adjust the solution pH=3, and filter;The filtrate obtained in the third step was extracted with an organic solvent dichloromethane (3×20 mL), and the organic phase was collected and dried over anhydrous sodium sulfate for 10 h;The organic phase obtained after the fourth step of drying was concentrated and dried to obtain 100 mg of a white powder, which was designated as sample 1.
According to the analysis of related databases, 3112-31-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Sciences Fujian Structure Of Matter Institute; Huang Deguang; Xiang Shiqun; Zhang Xiaofeng; (13 pag.)CN109369617; (2019); A;,
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