Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 478968-48-8, name is Ethyl 3-methoxy-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C7H10N2O3
(6-{3-Azabicyclo[3. 1 .0]hexan-3-yl}-2-methylpyridin-3-yl)methanol (410 mg), tributylphosphine (595 pL) and ethyl 3- methoxy-1H-pyrazole-4-carboxylate (340 mg) are dissolved in tetrahydrofuran (10 mL), cooled to -10 00 and treated with di-tert.-butyl azodicarboxylate (DBAD, 510 mg). Then the mixture is stirred for 30 minutes at room temperature. The mixture is purified by HPLC on reversed phase (acetonitrile, water, ammonia) to give the title compound.LC (Method 8): tR = 1.09 mm; Mass spectrum (ESIj: mlz = 357 [M+H].
The synthetic route of 478968-48-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FRATTINI, Sara; LINGARD, Iain; HAMPRECHT, Dieter, Wolfgang; BAKKER, Remko, Alexander; ECKHARDT, Matthias; GOLLNER, Andreas; HEHN, Joerg, P.; LANGKOPF, Elke; WAGNER, Holger; WELLENZOHN, Bernd; WIEDENMAYER, Dieter; (90 pag.)WO2018/192866; (2018); A1;,
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