These common heterocyclic compound, 19968-17-3, name is 4-Bromo-3-(trifluoromethyl)-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 4-Bromo-3-(trifluoromethyl)-1H-pyrazole
3-Methyl-4-nitrobenzyl chloride (0.77 g), 4-bromo-3-trifluoromethyl-lH-pyrazole (0.90 g) and po- tassium carbonate (0.57 g) were stirred in DMF (10 ml) at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate and washed with water and saturated aqueous solution of so- dium chloride. After drying the organic layer with magnesium sulfate, the solvent was distilled off under the reduced pressure and the obtained residue was purified by silica gel column chromatogra- phy to obtain 1- (3-methyl-4-nitrobenzyl)-4-bromo-3-trifluoromethyl-lH-pyrazole (0.9 g). ‘H-NMR (CDCl3, ppm): 2.58 (3H, s), 5.35 (2H, s), 7.24-7. 21 (2H, m), 7.49 (1H, s), 7. 98 (1H, d).
The synthetic route of 4-Bromo-3-(trifluoromethyl)-1H-pyrazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER CROPSCIENCE AG; WO2005/95351; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics