In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27258-32-8 as follows. Recommanded Product: 27258-32-8
17. Preparation of 3-difluoromethyl-1-methylpyrazole from 1-methylpyrazole-3-carbaldehydeAt -20° C., (diethylamino)sulfur trifluoride (DAST, 87.8 g, 0.54 mol) was added dropwise to a solution of 1-methylpyrazole-3-carbaldehyde (20 g, 0.18 mol) in methylene chloride (200 ml). The reaction mixture was stirred at room temperature overnight. The reaction mixture was then added carefully to ice/water (400 g) and extracted twice with methylene chloride (100 ml each). The combined organic phase was washed twice with water (100 ml each) and twice with NaCl solution (100 ml each) and dried over magnesium sulfate, and the solvent was removed under reduced pressure. The residue was separated by fractional distillation. 3-Difluoromethyl-1-methylpyrazole (16.5 g, transition temperature 141° C. at 570 mbar) was isolated in a purity of 95percent. This corresponds to a yield of 66.8percent.
According to the analysis of related databases, 27258-32-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BASF SE; US2010/174094; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics