Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 129768-28-1, name is 5-(Trifluoromethyl)-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Formula: C5H3F3N2O2
3-(Trifluoromethyl)-1H-pyrazole-5-carboxylic acid (Intermediate 15) (1.30 g, 7.20 mmol) was dissolved in acetonitrile (20 ml_), CDI (1.40 g, 8.66 mmol) was added portion-wise and the resulting mixture was stirred at room temperature for 2 h. Potassium 3-ethoxy-3-oxopropanoate (Intermediate 16) (1.22 g, 7.20 mmol) and MgCI2(823 mg, 7.20 mmol) were then added and the resulting reaction mixture was stirred at room temperature for 14 h. The mixture was concentrated in-vacuo, the residue was partitioned between H20 (40 ml_) and EtOAc (30 ml_) and the layers were separated. The aqueous layer was further extracted with EtOAc (2 x 30 ml_), the combined organic layers were dried (Na2S04) and the solvent was removed in-vacuo. The crude product was purified by triturating with pentane (decanting off the solvent) and dried under high vacuum to give ethyl 3-oxo-3-(3- (trifluoromethyl)-1H-pyrazol-5-yl)propanoate (1.20 g, 67 %) as a gum.LCMS (System 2, Method E): m/z 249 (M-H) (ESI -ve), at 4.47 min, 241 nm.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; HEPTARES THERAPEUTICS LIMITED; BROWN, Giles; CONGREVE, Miles; TEOBALD, Barry; FIELDHOUSE, Charlotte; SWAIN, Nigel; PICKWORTH, Mark; BOTTEGONI, Giovanni; (109 pag.)WO2020/79457; (2020); A1;,
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