Extracurricular laboratory: Synthetic route of 51985-95-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.

Some common heterocyclic compound, 51985-95-6, name is Methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H8N2O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C6H8N2O3

Example 134; (S, E)-Methyl 4-(6-(l-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-(5- methoxy-1-methyl-1H-pyrazol-3-yl)ethyl)-3-oxo-2>3-dihydropyridazin-4- yl)phenylcarbamate; 134 A. methyl 5 -methoxy-1 -methyl- 1H-pyrazole-3-carboxylate: To a cooled solution (0 °C) of methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (1.60 g, 10.25 mmol) and K2CO3 (2.124 g, 15.37 mmol) in DMF (10 mL) was added dropwise MeI (0.703 mL, 11.27 mmol). The reaction mixture was stirred under argon at rt for 5 days. The reaction mixture was diluted with EtOAc, washed with H2O (1 x 15 mL), saturated NaHCO3 (1 x 15 mL) and brine (1 x 15 mL). The organic phase was dried over MgSO^ filtered an Purification by normal phase chromatography gave 134A (1.20 g, 7.05 mmol, 68.8 percent yield) as a white solid. LC- MS (ESI) m/z: 171.2(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 51985-95-6, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2009/114677; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics