Reference of 34605-66-8, These common heterocyclic compound, 34605-66-8, name is 3-(2,5-Dimethyl-1H-pyrrol-1-yl)-1-methyl-1H-pyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
At -78 , 3- (2,5-dimethyl -1H- pyrrol-1-yl) -1-methyl -1H- pyrazole (708.5mg, 4.04mmol) in THF (8mL)Was added dropwise a solution of n-BuLi (2.4M in tetrahydrofuran, 2.5mL, 6.0mmol). The reaction system was stirred for 0.5 hours maintaining -78 , then0 moved after two hours while stirring. Acetone was added to the system (362.1mg, 6.24mmol), the resulting mixture was stirred at room temperature for 3Hours, then water (20 mL) to quench the reaction, and (50mL × 3) and extracted with ethyl acetate. The combined organic phases with saturated brine (50mL of), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (EtOAc / PE (v / v) = 1/5) of pureOf the title compound as a yellow oil (353.0mg, yield 37.4%).
The synthetic route of 34605-66-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Xi, Ning; Li, Minxiong; Li, Xiaobo; Dai, Weilong; Hu, Haiyang; Zhang, Tao; Chen, Wuhong; (105 pag.)CN105461694; (2016); A;,
Pyrazole – Wikipedia,
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