Related Products of 180207-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 180207-57-2 name is 2-(1H-Pyrazol-4-yl)ethanol, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
REFERENCE EXAMPLE 3 2-(1-Triphenylmethyl-3-pyrazolyl)ethanol, and 2-(1-triphenylmethyl-4-pyrazolyl)ethanol A mixture of 2-(3-pyrazolyl)ethanol and 2-(4-pyrazolyl)ethanol (2.4:1) (2.50 g) was dissolved in DMF (30 ml). To the solution were added, while stirring, triethylamine (2.26 g) and trityl chloride (6.22 g). The mixture was stirred at 25 C. for one hour, then at 40 C. for one hour. The reaction mixture was diluted with water, which was subjected to extraction with ethyl acetate. The organic layer was washed with an aqueous saline solution, which was dried over anhydrous magnesium sulfate, followed by concentration under reduced pressure. The concentrate was purified by means of a column chromatography (carrier: silica gel, 300 g, developing solvent: ethyl acetate-hexane, 1:1) to afford 2-(1-triphenylmethyl-3-pyrazolyl)ethanol (3.75 g) and 2-(1-triphenylmethyl-4-pyrazolyl)ethanol (1.42 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(1H-Pyrazol-4-yl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Chemical Industries, Ltd.; US6174877; (2001); B1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics