Electric Literature of 42027-81-6,Some common heterocyclic compound, 42027-81-6, name is 2-(4-Nitro-1H-pyrazol-1-yl)ethanol, molecular formula is C5H7N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 2a (0.32 g, 0.002 mol) was dissolved in 20 ml ethanol in a roundbottomedflask and Pd/C (10%, 0.1 g) was added which reacted at 60 Cfor 12 h under hydrogen atmosphere. The Pd/C was recycled by filtrationand the ethanol was recycled by evaporation to give the amineas purple oil which was retained in the round-bottomed flask. Theamine was used for next reaction without purification, because it waseasily oxidized. Then, added 6-bromo-4-chloroquinazoline (0.36 g,0.0015 mol) and isopropanol (30 ml) to the round-bottomed flask aboveand stirred at 90 C for 4 h. The isopropanol was removed under reducedpressure and the residue was purified through a column chromatographyon silica with chloroform/methanol (V:V 10:1) as a whitesolid (0.43 g, 86.0% yield).
The synthetic route of 42027-81-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ding, Huai-Wei; Wang, Shu; Qin, Xiao-Chun; Wang, Jian; Song, Hong-Rui; Zhao, Qing-Chun; Song, Shao-Jiang; Bioorganic and Medicinal Chemistry; vol. 27; 13; (2019); p. 2729 – 2740;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics