Related Products of 5203-77-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5203-77-0, name is 1,3-Dimethyl-1H-pyrazol-5-ol, This compound has unique chemical properties. The synthetic route is as follows.
At room temperature, 1,3-dimethyl-1hydro-pyrazole-5-ol (0.65 g, 0.0058 mol) and (0.48 g, 0.012 mol) sodium hydroxide were sequentially dissolved in 20 ml of dichloromethane.The low temperature bath was cooled to -4 C. To the above mixture was added dropwise 3,7-dichloro-5-(methylsulfonyl)-6-(((tetrahydrofuran-3-yl)methoxy)methyl)quinoline-8-carbonyl chloride (3.81 g, 0.0084 mol),The dropping rate was 4 drops / 30 seconds. After the addition was complete, the mixture naturally rose to room temperature and reacted for 5 hours.To the reaction mixture was added 10 ml of a saturated aqueous sodium hydrogen carbonate solution, and dichloromethane (3 * 15 ml) was extracted. The organic layers were combined, washed with water (1 * 15 ml), washed with saturated brine, and dried over anhydrous magnesium sulfate.The product was dissolved under reduced pressure to obtain 2.12 g of the product with a yield of 70%
The chemical industry reduces the impact on the environment during synthesis 1,3-Dimethyl-1H-pyrazol-5-ol. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shandong Joint Pesticide Co., Ltd.; Tang Jianfeng; Chi Huiwei; Wu Jianting; Yuan Xue; Liu Ying; (52 pag.)CN110615781; (2019); A;,
Pyrazole – Wikipedia,
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