Reference of 1031351-95-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1031351-95-7, name is Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of methyl 3-formyl-l-methyl-lH-pyrazole-5-carboxylate (Bellen Chem;l g, 5.95 mmol) in CH2CI2 (30 mL) at 0 C was added bis-(2-methoxyethyl)aminosulfur-trifluoride (3.29 mL, 17.8 mmol) in CH2CI2 (5 mL) dropwise via syringe pump over 40 minutes. The mixture was allowed to stir at 0 C for 20 minutes, then the ice-bath was removed, and the mixture was allowed to warm to ambient temperature. The mixture was then allowed to stir for an additional 90 minutes and was quenched by slow addition of saturated, aqueous NaHC( (25 mL) added via syringe pump over 1 hour. The mixture was diluted with CH2CI2 (15 mL), then the layers were separated, and the aqueous layer was extracted with CH2CI2 (3 x 7 mL). The combined organic fractions were dried over anhydrous Na2S04, filtered, and concentrated under reduced pressure. The residue was purified via column chromatography (S1O2, 50% ethyl acetate/heptanes) to give the title compound (1.01 g, 5.31 mmol, 89% yield). MS (ESI+) m/z 191 (M+H)+.
The chemical industry reduces the impact on the environment during synthesis Methyl 3-formyl-1-methyl-1H-pyrazole-5-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CALICO LIFE SCIENCES LLC; ABBVIE INC.; MARTIN, Kathleen, Ann; SIDRAUSKI, Carmela; FROST, Jennifer, M.; PLIUSHCHEV, Marina, A.; TONG, Yunsong; BLACK, Lawrence, A.; XU, Xiangdong; SHI, Lei; ZHANG, Qingwei, I.; CHUNG, Seungwon; SWEIS, Ramzi, Farah; DART, Michael, J.; RANDOLPH, John, T.; MURAUSKI, Kathleen; (674 pag.)WO2019/90076; (2019); A1;,
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