Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112758-40-4, name is 3-Methyl-1H-pyrazole-4-carbaldehyde, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H6N2O
In a 250-mL round-bottom flask, to a solution of 3-methyl- lH-pyrazole-4-carbaldehyde (2.2 g, 18.98 mmol, 1.00 equiv) in DMF (40 mL) was added sodium hydride (60% in oil, l .2g, 30.0 mmol, 1.58 equiv) at 0 C. The mixture was stirred for 1 h at room temperature, and then was added by 4-bromooxane (4 g, 23.03 mmol, 1.21 equiv). The reaction mixture was then stirred overnight at 120 C. When the reaction was done, it was quenched by the addition of water (20 mL) and the mixture was extracted with ethyl acetate (3 x 100 mL). The combined organic layers were washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The residue was purified by reverse phase flash chromatography eluting with MeOH in water (10% to 40% gradient in 60 min) to give a mixture of 3 -methyl- l-(tetrahy dro-2H-pyran-4-yl)-lH- pyrazole-4-carbaldehyde and 5-methyl-l -(tetrahydro-2H-pyran-4-yl)-l H-pyrazole-4- carbaldehyde as yellow oil (1.2 g, 1 :1 , 33%). MS: m/z = 195.2 [M+H]+
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 112758-40-4.
Reference:
Patent; MERCK PATENT GMBH; CALDWELL, Richard; LIU-BUJALSKI, Lesley; POTNICK, Justin; NEAGU, Constantin; KULKARNI, Shashank; JONES, Reinaldo; QIU, Hui; (238 pag.)WO2020/43638; (2020); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics