Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C4H3N3
To a solution of compound F5 (150 mg, 0.329 mmol) in acetone (5 mL) was added K2C03 (68.1 mg, 0.493 mmol) and 1 H-pyrazole-4-carbonitrile (45.8 mg, 0.493 mmol). After stirring at 25 C for 3 h, LCMS showed the reaction was complete. The reaction mixture was filtered, and the filtrate was concentrated in vacuum to give the crude product (150 mg). The crude product was purified by prep. HPLC (HC1) to give the desired product 170 (13 mg, 8.41%) as white solid. 1H NMR (170) (yield 8.4%): (400 MHz, CDC13) delta 7.86(s,lH), 7.81 (s, 1H), 5.03-4.87 (m, 2H), 3.54(d, J= 9.2Hz, 1H), 3.68-3.41 (m, 2H), 3.24 (d, J= 9.2Hz,lH), 2.59 (t, J= 9.2Hz, lH), 2.21- 1.15 (m, 29H), 0.65 (s, 3H). LCMS tR = 0.949 min in 1.5 min chromatography, 5-95AB, purity 98.6%, MS ESI calcd. for C28H42 3O3 [M+H]+ 467, found 450[M+H-18]+.
The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SAGE THERAPEUTICS, INC.; MARTINEZ BOTELLA, Gabriel; HARRISON, Boyd, L.; ROBICHAUD, Albert, Jean; SALITURO, Francesco, Gerald; HERR, Robert, Jason; KARGBO, Robert, Borbo; WO2015/27227; (2015); A1;,
Pyrazole – Wikipedia,
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