Some common heterocyclic compound, 2817-71-2, name is 1-Ethylpyrazole, molecular formula is C5H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 1-Ethylpyrazole
General procedure: In athree-necked bottle, 0.82 g (10 mmol)1-methylpyrazole and 1.25 g(10mmol) bromoethanolwere added into 10mL CH3CN. Then, themixtureswere stirred at reflux temperature for 48 h in a nitrogen atmosphere.After the reaction, the volatiles were removed under reducedpressure. The residual was washed several times by ethyl acetate togive a white solid. After filtration and drying in vacuum, the pureHEMPzBr was obtained: 1.532 g, yield 74%, white solid. 1H NMR(400 MHz, DMSO-d6) delta 8.58 (dd, J = 21.9, 2.8 Hz, 2H, Pz-H), 6.86 (t, J = 3.1 Hz, 1H, Pz-H), 5.26 (s, 1H, -OH), 4.61 (t, J = 5.0 Hz, 2H, -CH2-),4.20 (s, 3H, -CH3), 3.76 (t, J = 5.2 Hz, 2H, -CH2-).13C NMR (101 MHz,D2O) delta 138.38, 137.98, 107.43, 59.34, 52.34, 37.61. HR-MS (QTOF)calcd. for [C6H11N2O+] (m/z): 127.0866, found: 127.0868.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2817-71-2, its application will become more common.
Reference:
Article; Wang, Tengfei; Ma, Yuan; Jiang, Jiamin; Zhu, Xinrui; Fan, Baowan; Yu, Guanyao; Li, Ningning; Wang, Shasha; Ren, Tiegang; Wang, Li; Zhang, Jinglai; Journal of Molecular Liquids; vol. 293; (2019);,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics