In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 299930-70-4 as follows. Product Details of 299930-70-4
3-Chloro-1-methyl-4-nitro-1H-pyrazole (Stage K.2, 1 0 g 6 19 mmol) was shacked in MeOH/THF 1.1 (62 ml) under 1.1 bar H2 in presence of Raney nickel (0.35 g) as catalyst for 24 h at rt. The RM was filtered over Celite, the catalyst was washed several times with MeOH/THF and the filtrate was evaporated to dryness to give the title compound as a blue oil (HPLC tR 0.89 mm (Method A), M+H = 132 MS-ES).
According to the analysis of related databases, 299930-70-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; FURET, Pascal; KALTHOFF, Frank Stephan; MAH, Robert; RAGOT, Christian; STAUFFER, Frederic; WO2010/139731; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics