Adding a certain compound to certain chemical reactions, such as: 1146629-77-7, name is (4-(1H-Pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1146629-77-7, Formula: C15H17N5O2
37 in acetonitrile (619mg, 2.07mmol, Lin, Q. et al. Org. Lett., 2009, 11, to a solution (15mL) of the is preparation) described in 1999-2002, 51 (673mg, 5.17mmol), followed by the addition of DBU (650muL, 4.35mmol). The reaction was stirred for 15 hours at room temperature, and concentrated under reduced pressure. The resulting mixture of crude was diluted with water, and extracted with ethyl acetate (3x50mL). The combined organic layers were washed with 1N HCl, dried (Na2SO4), filtered and concentrated under reduced pressure. Normal phase column chromatography (SiO2, 0~60% ethyl acetate / hexanes) Purification on to give a white foam (+/-)-52 (447mg, 50%).
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Reference:
Patent; Concert Pharmaceuticals Inc.; Ai, Robert Silverman; Julie, F. Liu; Adam, J. Morgan; Bhomick, Panda; Scott, EL. Habeson; (43 pag.)JP2015/117185; (2015); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics