Electric Literature of 31037-02-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31037-02-2, name is Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Example 1 Ethyl 4-hydroxy-l-methyl-6-oxo-6,7-dihydro-lH-pyrazolo[3,4- delta]pyridine-5-carboxylate 3O ONaOEt / EtOH Reflux [00192] Sodium ethoxide (95%, 83g, 1.18 moles) was dissolved in 175 mL of absolute ethanol, following the protocol described in J. Heterocyclic Chem. (1978) 15:319 with some modifications. Diethylmalonate 2 (184.6 g, 1.18 moles) was added and stirred at room temperature for 10 minutes. Ethyl 5-amino-l-methylpyrazole-4-carboxylate 1 (5Og, 0.295 moles) was added slowly and the resulting solution refluxed overnight at 100 0C. During the reflux period, an off-white solid began to form. The solution was evaporated to dryness on a rotary evaporator and the residue dissolved in a minimum amount of water. Upon acidification (pH 2) of the aqueous solution with concentrated hydrochloric acid, the resulting precipitate was filtered and recrystallized from acetic acid-water to give 3 as a white solid (~45g , 64%). NMR (trifluoroacetic acid): delta 1.60(t.3H.J=7Hz, CH3 of ester), 4.22(s, 3H, N- CH3), 4.80 (q, 2H, j=7hz, CH2), 8.49 (s, IH, H-3)
The synthetic route of Ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GENENTECH, INC.; F. HOFFMANN-LA ROCHE AG; DOTSON, Jennafer; HEFFRON, Tim; OLIVERO, Alan G.; SUTHERLIN, Daniel P.; STABEN, Steven; WANG, Shumei; ZHU, Bing-Yan; CHUCKOWREE, Irina S.; FOLKES, Adrian J.; WAN, Nan Chi; WO2010/59788; (2010); A1;,
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