In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 82560-12-1 as follows. Recommanded Product: 82560-12-1
A suspension of Intermediate Rb (236 mg, 0.835 mmol), 3-tert-butyl-lH- pyrazole-5 -amine (Fluorochem, 122 mg, 0.88 mmol), copper(I) iodide (8.00 mg, 0.04 mmol), trans-N,N’-dimethylcyclohexane-l,2-diamine (23.8 mg, 0.17 mmol) and K2C03 (242 mg, 1.75 mmol) in degassed toluene (1 mL) was stirred at 100C under Ar for 3 h, and then heated to 150 C for 5 h using microwave irradiation. The cooled solution was partitioned between EtOAc (10 mL), water (5 mL) and concentrated aqueous ammonia (5 mL). The aqueous layer was extracted with EtOAc (10 mL), then the combined organics washed with water (10 mL), brine (10 mL), dried (Na2S04), filtered and concentrated in vacuo to leave a oil (305 mg). FCC, using 20-45%) EtOAc in cyclohexane, gave the title compound as an opaque sticky gum (129 mg, 53%). LCMS (Method 3): Rt 2.80 min, m/z 294 [MH+].
According to the analysis of related databases, 82560-12-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ALCARAZ, Lilian; HURLEY, Christopher; CRIDLAND, Andrew, Peter; JENNINGS, Andrew, Stephen, Robert; WO2014/195402; (2014); A1;,
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