52222-73-8, name is 4-(Trifluoromethyl)-1H-pyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-(Trifluoromethyl)-1H-pyrazole
[1615] a mixture of 4-(trifluoromethyl)-1H-pyrazole compound (1 g, 7.35 mmol), 2-chloropyrimidine (926 mg, 8.09 mmol) and K2CO3 (2.03 g, 14.7 mmol) in DMF(15 ml) was heated to 110 C for 12 hr. The mixture was added water (20 ml) and extracted with ethyl acetate (20 ml x 2), the organic phases were washed with brine (10 ml), dried over Na2SO4, filtered and concentrated. The residue was recrystallized by mtbe to give compound 410a (800 mg, yield: 50.8%) as yellow solid. 1H NMR (400mhz, CDCl3) delta 8.94 (s, 1h), 8.83 (d, 7 = 4.8 hz, 2h), 8.03 (s, 1h), 7.34 (t, 7 = 4.8 hz, 1h).
The synthetic route of 52222-73-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Pyrazole – Wikipedia,
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