In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59340-27-1, name is 1,3,5-Trimethyl-1H-pyrazole-4-sulfonyl chloride belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: pyrazoles-derivatives
E. General coupling protocol for the synthesis of compounds with general structure (249)Exemplified by the synthesis of N-((ls,4s)-4-fluoro-4-(3-(trifluoromethyl)phi sulfonyl)cyclohexyl)- 1 , 3, 5-trimethyl- lH-pyrazole-4- sulfonamide (251) [00330] Cis-4-fluoro-4-(3-(trifluoromethyl)phenylsulfonyl)cyclohexanamine (110) (75 mg, 0.21 mmol), TEA (111 mu,, 0.8 mmol), and l,3,5-trimethyl-lH-pyrazole-4- sulfonyl chloride (250) (0.21 mmol) were stirred at room temperature for 16 hours. The reaction was concentrated in vacuo and the crude material purified by reverse phase HPLC to give N-(Cis-4-fluoro-4-(3-(trifluoromethyl)phenylsulfonyl)cyclohexyl- 1 ,3,5-trimethyl- lH-pyrazole-4- sulfonamide (251).
The synthetic route of 59340-27-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan; GALEMMO, Robert; HOLLAND, Richard; ZHOU, Yuanxi; ZHU, Yongbao; SIMONSON, Eric; CHAHAL, Navjot; GRIMWOOD, Mike; WO2011/35159; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics